Scientific Name: Sus scrofa domestica
Taxonomy: Cellular organisms-> Eukaryota-> Opisthokonta-> Metazoa-> Eumetazoa-> Bilateria-> Deuterostomia-> Chordata-> Craniata-> Vertebrata-> Gnathostomata-> Teleostomi-> Euteleostomi-> Sarcopterygii-> Dipnotetrapodomorpha-> Tetrapoda-> Amniota-> Mammalia-> Theria-> Eutheria-> Boreoeutheria-> Laurasiatheria-> Artiodactyla-> Suina-> Suidae-> Sus-> Sus scrofa
Summary: This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The genome is polymorphic at this locus with allele-specific splice variants encoding different isoforms, based on the presence/absence of long homologous repeats (LHRs). The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in this gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus, sarcoidosis and Alzheimer's disease. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. [provided by RefSeq, May 2020] [NCBI] [Proteinatlas]
Data set information
| Project | Date | Technology | Tissue | Condition | Cell | PMID/DOI |
|---|---|---|---|---|---|---|
| Vthunter_0069 | 2021.04 | 10X Genomics | Frontal | Normal | 8812 | Link |
| Vthunter_0070 | 2021.04 | 10X Genomics | Occipital | Normal | 6829 | Link |
| Vthunter_0071 | 2021.04 | 10X Genomics | Parietal | Normal | 6162 | Link |
| Vthunter_0072 | 2021.04 | 10X Genomics | Hypothalamus | Normal | 7302 | Link |
| Vthunter_0073 | 2021.04 | 10X Genomics | Temporal | Normal | 3145 | Link |
| Vthunter_0074 | 2021.04 | iDrop | Lung | Normal | 13580 | Link |
| Vthunter_0074 | 2021.04 | iDrop | Lung | Normal | 13580 | Link |
| Vthunter_0074 | 2021.04 | iDrop | Lung | Normal | 13580 | Link |
| Vthunter_0074 | 2021.04 | iDrop | Lung | Normal | 13580 | Link |
| Vthunter_0074 | 2021.04 | iDrop | Lung | Normal | 13580 | Link |
| Vthunter_0074 | 2021.04 | iDrop | Lung | Normal | 13580 | Link |
| Vthunter_1013 | 2019.12 | 10X Genomics | Lung | Normal | 7465 | Link |
| Vthunter_1014 | 2019.12 | 10X Genomics | Lung | Normal | 3987 | Link |
Featureplot of receptors
Expression: Biased expression in small intestine (RPKM 3.0), colon (RPKM 2.7) and 7 other tissues?
